Specific OCT1 and ABCG2 polymorphisms are associated with Lamotrigine concentrations in Chinese patients with epilepsy
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- 作者：Chun-Hong Shen ; Yin-Xi Zhang ; Ru-Yi Lu ; Bo Jin ; Shan Wang ; Zhi-Rong Liu ; Ye-Lei Tang ; Mei-Ping Ding ; meipingd@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lamotrigine ; Pharmacogenetics ; OCT1 ; ABCG2 ; ABCC2 ; HNF4α
- 刊名：Epilepsy Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：186-190
- 全文大小：375 K
文摘
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We studied the effects of OCT1, ABCG2, ABCC2 and HNF4α polymorphisms on LTG concentrations and efficacy in epileptics.
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OCT1 rs628031 and ABCG2 rs2231142 were associated with normalized LTG concentration.
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No significant association between studied genotypes and LTG treatment response was found.