Antithrombotic activity of oral administered low molecular weight fucoidan from Laminaria Japonica
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- 作者：Xue Zhaoa ; Fengjun Guoa ; Jing Hua ; Lijuan Zhangb ; Changhu Xuea ; Zhaohui Zhanga ; Bafang Lia ; chenlis12@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：LMW heparin ; low molecular weight heparin ; MMW fucoidan ; medium molecular weight fucoidan ; LMW fucoidan ; low molecular weight fucoidan ; PMP ; 1-phenyl-3-methyl-5-pyrazolone ; APTT ; activated partial thromboplastin time ; TT ; thrombin time ; PT ; prothrombin time ; TXA2 ; thromboxane A2 ; TXB2 ; thromboxane B2 ; PGI2 ; prostacyclin ; 6-keto-PGF1α ; 6-keto prostaglandin F1α ; TFPI ; tissue factor pathway inhibitor ; t-PA ; tissue-type plasminogen activator ; u-PA ; urokinase-type plasminogen activator ; PLG ; plasmino
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：46-52
- 全文大小：473 K
文摘
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Reverse-phased HPLC method for fucoidan content analysis in blood and urine
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LMW fucoidan possessed higher absorption and bioavailability.
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Oral administration of LMW fucoidan exhibited excellent antithrombotic activity.
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Absorption played an important role on the antithrombotic activity of fucoidan.