Chewed ticagrelor tablets provide faster platelet inhibition compared to integral tablets: The inhibition of platelet aggregation after administration of three different ticagrelor formulations (IPAAD-Tica) study, a randomised controlled trial
详细信息 查看全文
- 作者：Dimitrios Venetsanos ; dimitrios.venetsanos@liu.se ; Sofia Sederholm Lawesson sofia.lawesson@liu.se ; Eva Swahn eva.swahn@liu.se ; Joakim Alfredsson joakim.alfredsson@liu.se
- 关键词：Pharmacodynamic ; Chewed ; Crushed ; VerifyNow ; Platelet ; Aggregation
- 刊名：Thrombosis Research
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：149
- 期：Complete
- 页码：88-94
- 全文大小：588 K
- 卷排序：149
文摘
Insufficient platelet inhibition during PCI increases the risk of periprocudural and early ischemic complications. Chewed or crushed ticagrelor administration improves the pharmacodynamic properties of orally administrated ticagrelor. Chewed ticagrelor as a loading dose is feasible and may provide a faster platelet inhibition compared to crushed ticagrelor tablets. The clinical efficacy and safety of chewed ticagrelor loading dose should be tested in large-scale clinical trials.