Managing uncontrolled postsplenectomy reactive thrombocytosis in idiopathic thrombocytopenic purpura: Role of thrombocytapheresis

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• 作者：Sudipta Sekhar Das ; Soumya Bhattacharya ; Subrata Sen
• 关键词：Thrombocytosis ; Thrombocytapheresis ; Plateletpheresis ; Cell separator ; Platelet
• 刊名：Transfusion and Apheresis Science
• 出版年：October, 2013
• 年：2013
• 卷：49
• 期：2
• 页码：171-173
• 全文大小：214 K

文摘

Reactive thrombocytosis occurs in response to infection, trauma, or surgery. Splenectomy alone accounts for 19% of all possible causes of extreme thrombocytosis. We performed thrombocytapheresis in a young lady with chronic idiopathic thrombocytopenic purpura (ITP) who developed postsplenectomy reactive thrombocytosis. Her post splenectomy platelet count was 227 脳 10⁶/ml which elevated to 1623 脳 10⁶/ml on the 7th postoperative day. A single thrombocytapheresis procedure reduced her platelet to 403 脳 10⁶/ml. She was discharged on the 10th postoperative day and then maintained a count of 204-238 脳 10⁶/ml with aspirin. Thrombocytapheresis reduces the platelet count rapidly in thrombocytosis and prevents patients from having thrombotic events. However, such procedures should be performed very meticulously to ensure patient safety.