Probing the interaction of a glycoprotein IIb/IIIa receptor antagonist with bound platelets using electrochemical impedance

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• 作者：Bincy Jose ; ^{bincy.jose@dcu.ie} ; Elaine Spain ; Kellie Adamson ; Eadaoin Carthy ; David Boyle ; Robert J. Forster ; ^{Robert.Forster@dcu.ie}
• 关键词：Platelet ; Impedance ; ReoPro ; Fibrinogen ; Whole blood ; Patterned protein
• 刊名：Electrochemistry Communications
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：75
• 期：Complete
• 页码：69-72
• 全文大小：666 K
• 卷排序：75

文摘

Patterned protein surfaces can provide an improved assay for monitoring antiplatelet therapy. Patterning significantly influences the spreading of platelets compared to conventional, homogeneously coated surfaces. Electrochemical impedance can be used to rapidly measure the surface coverage of platelets without the need for labelling.