Synthesis of 2-thia-4-azabicyclo[3.3.1]non-3-en-3-amine - bridged nitric oxide synthase inhibitor with enhanced lipophilicity

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• 作者：Olga N. Zefirova^a ; ^b ; ^{olgaz@org.chem.msu.ru} ; Evgeniya D. Plotnikova^a ; Evgeniya V. Nurieva^a ; Danil I. Peregud^c ; ^{peregud_d@yahoo.com} ; Mikhail V. Onufriev^d ; Natalia V. Gulyaeva^d ; ^{nata_gul@pisem.net}
• 刊名：Mendeleev Communications
• 出版年：2013
• 出版时间：March-April, 2013
• 年：2013
• 卷：23
• 期：2
• 页码：76-77
• 全文大小：363 K

文摘

2-Thia-4-azabicyclo[3.3.1]non-3-en-3-amine was synthesized as a lipophilic analogue of NO-synthase inhibitor 2-amino-5,6-dihydro- 4H-1,3-thiazine and found to be a potent inhibitor of inducible NO-synthase in vitro. The crystal structure of the key intermediate 2-thia-4-azabicyclo[3.3.1]nonane-3-thione (obtained by cyclization of trans-3-bromocyclohexylamine with carbon disulfide) was determined by X-ray analysis.