Structural Basis of Lipid Targeting and Destruction by the Type V Secretion System of Pseudomonas aeruginosa
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- 作者：Paulo Vinicius da Mata Madeira1 ; Samira Zouhir1 ; Pauline Basso2 ; 3 ; 4 ; 5 ; David Neves1 ; Auré ; lie Laubier6 ; Richard Salacha6 ; Sophie Bleves6 ; Eric Faudry2 ; 3 ; 4 ; 5 ; Carlos Contreras-Martel3 ; 4 ; 7 ; carlos.contreras@ibs.fr" class="auth_mail" title="E-mail the corresponding author ; André ; a Dessen1 ; 3 ; 4 ; 7 ; andrea.dessen@ibs.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATs ; autotransporters ; TPS ; two-partner secretion ; PLPs ; patatin-like proteins ; SEC ; size exclusion chromatography ; PIs ; phosphatidyl inositols
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：8 May 2016
- 年：2016
- 卷：428
- 期：9
- 页码：1790-1803
- 全文大小：1840 K
文摘
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PlpD is a PLA1 secreted by P. aeruginosa through the T5Vd secretion system.
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PlpD's compact lipase fold harbors a catalytic dyad and a trapped lipid in the cleft.
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PlpD broadly recognizes phosphatidyl inositols and disrupts membrane architecture.