How direct competition shapes coexistence and vaccine effects in multi-strain pathogen systems
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- 作者：Erida Gjinia ; egjini@igc.gulbenkian.pt" class="auth_mail" title="E-mail the corresponding author ; Carina Valentee ; Raquel Sá ; -Leã ; oe ; M. Gabriela M. Gomesb ; c ; d
- 关键词：Ecology ; Neutral model ; Co-infection ; Pneumococcus ; Bayesian inference ; PCV7
- 刊名：Journal of Theoretical Biology
- 出版年：2016
- 出版时间：7 January 2016
- 年：2016
- 卷：388
- 期：Complete
- 页码：50-60
- 全文大小：756 K
文摘
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We study how direct competition at co-colonization shapes multi-strain coexistence.
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We consider neutral and non-neutral models varying symmetry assumptions for clone interactions.
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The nested models are applied to pneumococcus prevalence data post-vaccination in Portugal.
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Our framework co-estimates transmission, competition and vaccine efficacy parameters.
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