Minimal selective concentrations of tetracycline in complex aquatic bacterial biofilms
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- 作者：Sara V. Lundströ ; ma ; Marcus Ö ; stmanb ; Johan Bengtsson-Palmea ; Carolin Rutgerssona ; Malin Thoudala ; Triranta Sircarc ; Hans Blanckc ; K. Martin Erikssond ; Mats Tysklindb ; Carl-Fredrik Flacha ; D.G. Joakim Larssona ; joakim.larsson@fysiologi.gu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARG ; antibiotic resistance gene ; CFU ; colony forming unit ; EC50 ; concentration at 50% effect ; LC-MS/MS ; liquid chromatography-tandem mass spectrometry ; MIC ; minimal inhibitory concentration ; MSC ; minimal selective concentration ; PICT ; pollution-induced community tolerance ; qPCR ; quantitative polymerase chain reaction ; TC ; tetracycline
- 刊名：Science of the Total Environment
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：553
- 期：Complete
- 页码：587-595
- 全文大小：609 K
文摘
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Methods to determine minimal selective concentrations of antibiotics were compared.
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One μg/L tetracycline selects for tetA and tetG genes in freshwater biofilms.
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Ten μg/L tetracycline selects for phenotypic resistance.
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Selective concentrations overlap with those reported in sewage treatment plants.
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Approach described could be used in risk assessment of other antibiotics as well.