Polychlorinated biphenyl exposure and deiodinase activity in young infants
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- 作者：Shalini D. Soechitrama ; Sietske A. Berghuisa ; s.a.berghuis@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; Theo J. Visserb ; Pieter J.J. Sauera
- 关键词：D1 ; 2 ; 3 ; iodothyronine deiodinases type 1 ; 2 and 3 ; fT4 ; free thyroxine ; OH-PCB ; hydroxylated polychlorinated biphenyl ; PCB ; polychlorinated biphenyl ; POPs ; persistent organic pollutants ; rT3 ; reverse triiodothyronine ; T3 ; triiodothyronine ; T4 ; thyroxine ; T4S ; T4 sulfate ; TBG ; thyroid binding globulin ; TEQ ; toxic equivalent ; T4 ; thyroxin ; TH ; thyroid hormone ; TSH ; thyroid stimulating hormone ; TTR ; transthyretin
- 刊名：Science of the Total Environment
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：574
- 期：Complete
- 页码：1117-1124
- 全文大小：381 K
文摘
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Prenatal levels of 6 PCBs were positively correlated with cord serum T3.
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4 PCBs showed a negative correlation with cord serum reverse T3.
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5 PCBs were positively correlated with cord serum T3/rT3 ratio.
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Prenatal exposure to PCBs might reduce deiodinase 3 activity.
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Reduction of deiodinase 3 activity is a potential mechanism of PCB toxicity in humans.