Characterization of polymeric nanoparticles for intravenous delivery: Focus on stability

详细信息    查看全文

• 作者：Claudia L. Oliveira^a ; ^b ; ^c ; ^d ; Francisco Veiga^d ; Carla Varela^d ; Fernanda Roleira^d ; ^e ; Elisiá ; rio Tavares^d ; ^e ; Isabel Silveira^a ; ^b ; ^c ; Antonio J. Ribeiro^a ; ^b ; ^d ; ^{aribeiro@ff.uc.pt}
• 关键词：Biological stability ; Bovine serum albumin ; Physicochemical characterization ; Poly allylamine hydrochloride ; Poly(lactic-co-glycolic) acid ; Mouse and human plasma
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：150
• 期：Complete
• 页码：326-333
• 全文大小：1248 K
• 卷排序：150

文摘

Polymeric NP stability within biological media is still poorly investigated. In vitro stability of NP in different media is independent of NP surface. Pronounced difference after incubation in mouse and human plasma. NP aggregation related to medium total protein concentration.