Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase

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• 作者：Kamil Hercí ; k^a ; Jaroslav Kozak^a ; Michal &Scaron ; á ; la^a ; Milan Dejmek^a ; Hubert Hřebabecký ; ^a ; Eva Zborní ; ková ; ^a ; Miroslav Smola^a ; Daniel Ruzek^b ; ^c ; Radim Nencka^a ; ^{nencka@uochb.cas.cz} ; Evzen Boura^a ; ^{boura@uochb.cas.cz}
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：Complete
• 页码：131-133
• 全文大小：625 K
• 卷排序：137

文摘

An active recombinant Zika virus RNA-dependent RNA polymerase (RdRp) was prepared. An in vitro assay to measure its activity was developed. Nucleoside triphosphate (NTP) analogs that inhibit ZIKV RdRp are described. 2′-C-methylated NTPs inhibit ZIKV RdRp as expected. Unexpectedly, two structurally new active compounds were discovered among conformationally locked NTPs.