Optimizing JC and BK polyomavirus IgG testing for seroepidemiology and patient counseling
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- 作者：Piotr Kardasa ; Cé ; line Leboeufa ; Hans H. Hirscha ; b ; c ; hans.hirsch@unibas.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：BKPyV ; BK polyomavirus ; ELISA ; enzyme-linked immunosorbent assay ; HPyV ; human polyomavirus ; Ig ; immunoglobulin ; JCPyV ; JC polyomavirus ; MS ; multiple sclerosis ; PML ; progressive multifocal leukoencephalopathy ; nOD ; normalized optical density ; PyVHC ; polyomavirus-associated hemorrhagic cystitis ; PyVAN ; polyomavirus-associated nephropathy ; VLP ; virus-like particle ; VP1 ; viral capsid protein 1
- 刊名：Journal of Clinical Virology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：71
- 期：Complete
- 页码：28-33
- 全文大小：980 K
文摘
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JCPyV and BKPyV serology may help to identify immunocompromized patients at risk.
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Serial serum dilutions provide semi-quantitative JCPyV- and BKPyV-IgG ELISA levels.
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For seroprevalence, 200-fold dilution is best (false-positive 1%, false-negative 1%).
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For patient counseling, 100-fold dilution is most sensitive, but needs preadsorption.
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