Ataxin-1 regulates proliferation of hippocampal neural precursors
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- 作者：M. Asher&dagger ; ; A. Johnson&dagger ; ; B. Zecevic ; D. Pease ; M. Cvetanovic ; mcvetano@umn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer&rsquo ; s disease ; BrdU ; 5-bromo-2&prime ; -deoxyuridine ; Ct ; threshold cycle ; DG ; dentate gyrus ; FGF ; fibroblast growth factor ; HRP ; horseradish peroxidase ; NPCs ; neural precursor cells ; polyQ ; polyglutamine ; SCA1 ; spinocerebellar ataxia type 1
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：322
- 期：Complete
- 页码：54-65
- 全文大小：2307 K
文摘
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Atxn1−/− mice have reduced adult hippocampal neurogenesis.
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Atxn1−/− hippocampal neural precursor cells (NPCs) proliferate less in vitro.
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Transfection of mutant ATXN1[82Q] into wild-type NPCs inhibits their proliferation.