Hippo/MST1 signaling mediates microglial activation following acute cerebral ischemia-reperfusion injury
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- 作者：Siqi Zhaoa ; Jie Yina ; b ; Lujun Zhoua ; b ; Feng Yanc ; Qing Hea ; b ; Li Huanga ; Shengyi Penga ; Junying Jiae ; Jinbo Chenga ; Hong Chena ; Wufan Taod ; Xunming Jic ; Yun Xuf ; Zengqiang Yuana ; zqyuan@ibp.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ischemia ; Microglia ; Hippo/MST1 ; Src ; IκB
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：55
- 期：Complete
- 页码：236-248
- 全文大小：2831 K
文摘
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MST1 is involved in microglial activation induced by brain ischemic stroke.
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Src acts as the upstream of MST1 in microglial activation.
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MST1 regulates inflammatory factors release through NF-κB pathway.
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Loss of MST1 in microglia/macrophage protects cerebral ischemia-induced brain injury.