Determination of clinical significance of coagulase-negative staphylococci in blood cultures

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• 作者：Asiye Karakullukç ; u ; ^{asiyekarakullukcu@gmail.com} ; Mert Ahmet Kuşkucu ^{kuskucum@gmail.com} ; Sevgi Ergin ^{sevgiergin@yahoo.com} ; Gö ; khan Aygü ; n ^{gokhanaygun67@yahoo.com} ; Kenan Midilli ^{kmidilli@istanbul.edu.tr} ; Ö ; mer Kü ; ç ; ü ; kbasmaci ^{obasmaci@istanbul.edu.tr}
• 关键词：Coagulase negative Staphylococci ; Bacteremia ; Blood culture ; Contamination ; RAPD-PCR
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：87
• 期：3
• 页码：291-294
• 全文大小：282 K
• 卷排序：87

文摘

The aim of this study was to investigate the criteria used to distinguish coagulase-negative staphylococci (CoNS) bacteremia from contamination. We evaluated 162 adult patients with CoNS-positive blood cultures (BCs). Of the 162 patients, 35 (21.6%) had at least 2 positive BCs and 127 (78.4%) had a single positive BC. According to the Laboratory-Confirmed Bloodstream Infection (LCBI) criteria, 24 (14.8%) patients with the same species of CoNS had true bacteremia, and 138 (85.2%) patients had contaminants. Despite the detection of the same CoNS species, 9 of the 24 patients had different CoNS genotypes. Using clinical assessments, only 20 patients were diagnosed with true bacteremia, 8 of them had a single positive BC. We concluded that only using the LCBI criteria or clinical evaluations of a patient were not sufficient to distinguish CoNS bacteremia from contamination. Molecular identification should also be performed as a diagnostic laboratory parameter for CoNS bacteremia.