- 作者：Stephanie A. Savory ; Nnenna G. Agim ; Rui Mao ; Shayna Peter ; Casey Wang ; Gerardo Maldonado ; Jessica Bearden Dietert ; Tiffany Jane Lieu ; Christy Wang ; Kara Pretzlaff ; Shinjita Das ; Travis V ; ergriff ; Isha E. Lopez ; Br ; on R. Litzner ; Linda S. Hynan ; Maria Ivonne Arellano-Mendoza ; Paul R. Bergstresser ; Amit G. P ; ya
- 关键词：acne vulgaris ; clinical trials ; evidence-based medicine ; hyperpigmentation ; outcome measures ; pigment ; pigmentation ; postinflammatory ; postinflammatory hypermelanosis ; skin of color ; validation
- 刊名：Journal of the American Academy of Dermatology
- 出版年：January, 2014
- 年：2014
- 卷：70
- 期：1
- 页码：108-114
- 全文大小：644 K
Background
There are no validated outcome measures for postinflammatory hyperpigmentation (PIH).Objective
We sought to determine the reliability and validity of an outcome measure for PIH after acne in patients with skin of color.
Methods
A postacne hyperpigmentation index (PAHPI) was developed. Six raters scored 21 patients with PIH twice. Reliability was determined within and between raters, whereas validity was evaluated by comparing scores with severity ranking by an independent dermatologist. The pigment intensity scores were compared with the melanin index of each patient using a narrowband reflectance spectrophotometer. A quality-of-life score (Skindex-29) was also compared with PAHPI scores.
Results
Total PAHPI scores showed good reliability within and between raters and were valid when compared with clinical severity and melanin indices. Good correlation was achieved between the total PAHPI score and the emotion subscale of the Skindex-29.
Limitations
Generalizability of results is limited to African American females.
Conclusion
The PAHPI shows good reliability and validity when scored on patients with PIH from acne vulgaris. The PAHPI also correlates well with the emotional impact of PIH as measured by the Skindex-29. Future studies should assess the ability of the PAHPI to change with improvement of PIH from acne after treatment.