Molecular characterization and functional analysis of four teleostean K⁺ channels in macrophages of sea perch (Lateolabrax japonicas)

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• 作者：Bailin Cong^a ; ^b ; Yingmei Chai^c ; Bo Wang^b ; ^{ousun@fio.org.cn} ; Shenghao Liu^b ; Jihong Shen^b ; Nengfei Wang^a ; ^b ; Quanqi Zhang^a ; Xiaohang Huang^b
• 关键词：Voltage-gated potassium ion channels ; Sea perch Lateolabrax japonicas ; Macrophages ; LPS ; Immune function
• 刊名：Fish & Shellfish Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：426-435
• 全文大小：2608 K
• 卷排序：60

文摘

Isolate and characterize four voltage-gated potassium channels genes from macrophages of Sea perch. K+ channel blockers downregulated TNF-α and IL1-β in LPS-induced macrophages. K+ channel blocker suppressed the ROS production and proliferation of LPS-activated macrophages. Most of Kv we found may play an important role in modulating the immune function of Sea perch macrophages.