Methylphenidate alters flash-evoked potentials, body temperature, and behavior in Long-Evans rats

详细信息    查看全文

• 作者：Bruce E. Hetzler ; Katherine R. Meckel ; Bruce A. Stickle
• 关键词：Methylphenidate ; Visual cortex ; Superior colliculus ; Flash-evoked potentials ; Rats ; Behavior
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：January, 2014
• 年：2014
• 卷：116
• 期：Complete
• 页码：75-83
• 全文大小：1220 K

文摘

This experiment examined the effects of methylphenidate hydrochloride on flash-evoked potentials (FEPs) recorded from the visual cortex (VC) and superior colliculus (SC) of chronically implanted male Long-Evans rats, as well as on body temperature and open field behavior. FEPs were recorded at 10, 20 and 40 min following intraperitoneal injections of saline, and of doses of 0.7, 2.9, and 11.6 mg/kg methylphenidate on separate days. The 0.7 mg/kg dose did not produce significant effects. In the VC, following administration of the 11.6 mg/kg dose of methylphenidate the amplitude of components P₈₃, N₁₄₆, and P₂₃₂ decreased, the amplitude of component N₆₄ briefly increased and components P₂₃, N₃₀, N₄₀, and P₄₈ were unchanged in amplitude. In the SC, component P₂₉ was unaffected, while components P₃₈ and N₅₁ were reduced in amplitude by the 11.6 mg/kg dose of methylphenidate. Peak latencies of components N₄₀, P₄₈, P₈₃, and N₁₄₆ in the VC and component P₃₈ in the SC were increased by the 11.6 mg/kg dose of methylphenidate. When body temperature was recorded 45 min after drug administration, a mild dose-dependent hypothermia was found with the 2.9 and 11.6 mg/kg methylphenidate doses, suggesting that this may have contributed to the increased latencies. In subsequent open field observations, both line crossings and rearings were significantly increased by the 11.6 mg/kg dose. Increased movement into the center of the testing area was also observed, which could be a sign of increased exploration and reduced anxiety following methylphenidate.