Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation
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- 作者：Erica A. Dalea ; 1 ; 2 ; Daryl P. Fieldsa ; b ; 1 ; Michael J. Devinneya ; Gordon S. Mitchella ; b ; gsmitche@phhp.ufl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：5HT ; serotonin ; AIH ; acute intermittent hypoxia ; BDNF ; brain derived neurotrophic factor ; CtB ; choleratoxin B fragment ; ERK ; extracellular regulated kinase ; LTP ; long term potentiation ; Nx ; normoxia ; (p)LTF ; (phrenic) long-term facilitation ; siNT ; non-targeting siRNA ; siTrkB ; siRNA targeting TrkB ; TrkB ; tropomyosin related kinase B
- 刊名：Experimental Neurology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：287
- 期：part_P2
- 页码：130-136
- 全文大小：851 K
文摘
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Acute intermittent hypoxia-induced respiratory motor plasticity requires BDNF signaling.
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Phrenic motor neurons express the high affinity BDNF receptor TrkB.
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Intrapleural siRNA targeting TrkB receptors decreased TrkB receptor expression selectively on phrenic motor neurons.
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Intrapleural siRNA targeting TrkB receptors abolished BDNF dependent, hypoxia-induced respiratory motor plasticity.
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Phrenic motor neurons are a critical site for spinal respiratory motor plasticity.
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