Identification and characterization of a TAB1 gene involved in innate immunity of amphioxus (Branchiostoma belcheri)
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- 作者：Denghua Yina ; Wenjuan Lia ; Meili Fua ; Liming Chenb ; Fei Maa ; Ping Jina ; jinping8312@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：TAK1 ; transforming growth factor-β activated kinase-1 ; TAB1 ; TAK1-binding protein 1 ; TLR ; toll-like receptor ; TNF ; tumor necrosis factor ; IL-1 ; interleukin-1 ; cDNA ; DNA complementary to RNA ; AmphiTAB1 ; amphioxus TAK1-binding protein 1 ; bp ; base pair(s) ; ORF ; open reading frame ; PP2Cc ; serine/threonine phosphatases ; family 2C ; catalytic ; RT-PCR ; reverse transcription-PCR ; MAPKs ; mitogen-activated protein kinases ; MAP3K7 ; mitogen-activated protein kinase kinase kinase 7 ; NF-κB ; nuclear factor κB
- 刊名：Gene
- 出版年：2016
- 出版时间：10 January 2016
- 年：2016
- 卷：575
- 期：2
- 页码：294-302
- 全文大小：1981 K
文摘
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AmphiTAB1 gene was cloned from Branchiostoma belcheri with a 2281 bp cDNA product.
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AmphiTAB1 gene was located between invertebrates and vertebrates.
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AmphiTAB1 was ubiquitously and differentially expressed in six investigated tissues.
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AmphiTAB1 gene was involved in the innate immune response of LPS stimulation.
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AmphiTAB1 protein expressed in vitro shows a band with a molecular mass of 80 kDa and Western blot confirmed it.