HMGA2 promotes adipogenesis by activating C/EBPβ-mediated expression of PPARγ
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- 作者：Yang Xia ; Wanjing Shena ; Lili Maa ; Ming Zhaoa ; Jiachen Zhenga ; Shizhong Bua ; bushizhong@nbu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Shinjiro Hinob ; Mitsuyoshi Nakaob ; c ; mnakao@gpo.kumamoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adipogenesis ; HMGA2 ; C/EBPβ ; PPARγ
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：472
- 期：4
- 页码：617-623
- 全文大小：1679 K
文摘
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Overexpression of HMGA2 has been implicated in obesity in mice and humans.
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HMGA2 is required for adipocyte formation.
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HMGA2 colocalizes with C/EBPβ and is required for C/EBPβ recruitment to Pparγ2 promoter.
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HMGA2 and C/EBPβ cooperatively enhance the Pparγ2 promoter activity.