Inhibitory effects of the dietary flavonoid quercetin on the enzyme activity of zinc(II)-dependent yeast alcohol dehydrogenase: Spectroscopic and molecular docking studies
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- 作者：Sutanwi Bhuiya<sup> ; sup><sup>s.bhuiya12@gmail.comsup> ; Lucy Haque <sup>lucy.haque@gmail.comsup> ; Ankur Bikash Pradhan <sup>ankurpradhan727@gmail.comsup> ; Suman Das<sup> ; sup><sup>sumandas10@yahoo.comsup>
- 关键词：Quercetin-Zn2+ complexation ; Alcohol dehydrogenase (ADH) ; Structural alteration and enzyme inhibition
- 刊名：International Journal of Biological Macromolecules
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：95
- 期：Complete
- 页码：177-184
- 全文大小：1838 K
- 卷排序：95
文摘
Quercetin (QTN), a flavonol forms complex with Zn2+ in a mole ratio of 2:1 in terms of qtn:Zn2+. Activity of zinc dependent enzyme yeast alcohol dehydrogenase (ADH) is inhibited through non-competitive inhibition in presence of QTN. This inhibition is attributed to the conformational change of the enzyme due to complexation followed by abstraction of Zn2+ from ADH by QTN.