Depression and anxiety symptoms in Spanish adult patients with cystic fibrosis: associations with health-related quality of life

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• 作者：C. Olveira ; M.D. ; Ph.D.^a ; ^{casi1547@separ.es" class="auth_mail" title="E-mail the corresponding author} ; A. Sole ; M.D. ; Ph.D.^b ; ^{sole_amp@gva.es" class="auth_mail" title="E-mail the corresponding author} ; R.M. Giró ; n ; M.D. ; Ph.D.^c ; ^{rmgiron@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; E. Quintana-Gallego ; M.D.^d ; ^e ; ^{esther.quintana@telefonica.net" class="auth_mail" title="E-mail the corresponding author} ; P. Mondejar ; M.D.^f ; ^{pmondejarlopez@yahoo.es" class="auth_mail" title="E-mail the corresponding author} ; F. Baranda ; M.D.^g ; ^{felixmaria.barandagarcia@osakidetza.net" class="auth_mail" title="E-mail the corresponding author} ; ^{felixbaranda@outlook.com" class="auth_mail" title="E-mail the corresponding author} ; A. Alvarez ; M.D.^h ; ^{aalvarez@vhebron.net" class="auth_mail" title="E-mail the corresponding author} ; C. Prados ; M.D. ; Ph.D.ⁱ ; ^{conchaprados@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; J. Rodrí ; guez-Gonzá ; lez ; M.D.^j ; ^{jesusrgtej@terra.es" class="auth_mail" title="E-mail the corresponding author} ; ^{jesusrgtej@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; I. Herrero-Labarga ; M.D.^k ; ^{miherrerol@salud.aragon.es" class="auth_mail" title="E-mail the corresponding author} ; A. Quittner ; Ph.D.^l ; ^{aquittner@miami.edu" class="auth_mail" title="E-mail the corresponding author} ; G. Olveira ; M.D. ; Ph.D.^m ; ⁿ ; ^{gabrielm.olveira.sspa@juntadeandalucia.es" class="auth_mail" title="E-mail the corresponding author} ; ^{gabrielm.olveira.sspa@juntadeandalucia.es" class="auth_mail" title="E-mail the corresponding author} ; ^{gabrielolveiracasa@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cystic fibrosis ; Quality of life ; Anxiety ; Depression ; Lung function
• 刊名：General Hospital Psychiatry
• 出版年：2016
• 出版时间：May-June 2016
• 年：2016
• 卷：40
• 期：Complete
• 页码：39-46
• 全文大小：499 K

文摘

Cystic fibrosis (CF) is a chronic disease with an impact on the quality of life. Self-reported symptoms of depression and anxiety were assessed in the Spanish cohort of the International Epidemiological Study on Depression and Anxiety in patients with CF (International Depression-Anxiety Epidemiological Study) and their relationship with health status and health-related quality of life (HRQoL) was evaluated.

Methods

This cross-sectional study recruited adult patients with CF at 10 Spanish centers. Patients completed the Hospital Anxiety and Depression Scale (HADS) and the Revised Cystic Fibrosis Questionnaire. Demographic and health data were recorded from medical charts. Logistic regression was used to determine the predictors of elevated symptoms of depression and anxiety (HADS ≥ 8).

Results

Of the 336 participants recruited (mean age, 28.1 years; 48.2% women), 41 (12.2%) had elevated depression-related scores, and 100 (29.7%) had elevated anxiety-related scores (HADS ≥ 8). After adjusting for confounders, only less education, intravenous antibiotics, psychiatric medications and psychotherapy were significantly associated with elevated psychological symptoms. Specifically, regardless of lung function, patients who were depressed or anxious reported worse HRQoL.

Conclusions

The prevalence of elevated symptoms of depression and anxiety was high in Spanish adult patients with CF, and these symptoms were associated with a decreased HRQoL.