Monoubiquitination of Histone H2B Blocks Eviction of Histone Variant H2A.Z from Inducible Enhancers
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- 作者：Gregory Segala1 ; 2 ; Marcela A. Bennesch1 ; 2 ; Deo Prakash Pandey1 ; 3 ; Nicolas Hulo2 ; Didier Picard1 ; 2 ; 4 ; didier.picard@unige.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：chromatin ; ubiquitylation ; epigenetics ; transcription initiation ; transcription factor ; chromatin remodeling ; histone ; estrogen receptor ; INO80 ; breast cancer
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：20 October 2016
- 年：2016
- 卷：64
- 期：2
- 页码：334-346
- 全文大小：4873 K
文摘
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Monoubiquitination of histone H2B (H2Bub1) represses inducible enhancers
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At the center of inducible enhancers, H2Bub1 levels decrease to form H2Bub1 valleys
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The histone variant H2A.Z is stabilized by H2Bub1 at inducible enhancers
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H2Bub1 impairs chromatin access to INO80, an H2A.Z evictor