Acute and subchronic toxicity of inhaled toluene in male Long-Evans rats: Oxidative stress markers in brain
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- 作者：Prasada Rao S. Kodavantia ; kodavanti.prasada@epa.gov" class="auth_mail" title="E-mail the corresponding author ; Joyce E. Roylandb ; Debra A. Moore-Smitha ; Jonathan Besasa ; Judy E. Richardsc ; Tracey E. Beasleya ; Paul Evanskyd ; Philip J. Bushnella
- 关键词：TAS ; total antioxidant substances ; GSH ; glutathione ; GCS ; γ-glutamylcysteine synthetase ; GST ; glutathione-S-transferase ; GRD ; glutathione reductase ; GPX ; glutathione peroxidase ; NQO1 ; NAD(P)H ; quinone oxidoreductase ; UBIQ-RD ; NADH ubiquinone reductase ; SOD ; superoxide dismutase ; TA ; total aconitase
- 刊名：Neurotoxicology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：51
- 期：Complete
- 页码：10-19
- 全文大小：1862 K
文摘
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Subchronic toluene exposure increased markers of ROS, decreased antioxidants and increased protein carbonyls to indicate protein damage.
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Acute exposure to toluene affected oxidative stress parameters to a lesser extent than did subchronic exposure.
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Toluene induced OS in the brain may be a possible adverse outcome pathway for some of the neurotoxic effects.