Metabolic engineering of Saccharomyces cerevisiae for the overproduction of short branched-chain fatty acids
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- 作者：Ai-Qun Yua ; b ; Nina Kurniasih Pratomo Juwonoa ; b ; Jee Loon Fooa ; b ; Susanna Su Jan Leonga ; b ; c ; Matthew Wook Changa ; b ; bchcmw@nus.edu.sg" class="auth_mail" title="E-mail the corresponding author
- 关键词：Short branched-chain fatty acids ; Ehrlich pathway ; Transporters ; Saccharomyces cerevisiae
- 刊名：Metabolic Engineering
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：34
- 期：Complete
- 页码：36-43
- 全文大小：978 K
文摘
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The first report on improving biosynthesis of SBCFAs in Saccharomyces cerevisiae.
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Chromosome-based combinatorial gene overexpression.
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Elimination of genes in competitive pathways.
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31.2-fold increase in SBCFA production by metabolic engineering strategies.
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Accelerated SBCFA secretion by overexpression of the transporter Pdr12p.