Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice

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• 作者：Maria Elizabeth de Sousa Rodrigues^a ; ^c ; ¹ ; ³ ; ^{mdesou2@emory.edu} ; Mandakh Bekhbat^a ; ¹ ; ^{mandakh.bekhbat@emory.edu} ; Madelyn C. Houser^a ; ¹ ; ^{mcrawf4@emory.edu} ; Jianjun Chang^a ; ¹ ; ^{jchan47@emory.edu} ; Douglas I. Walker^b ; ² ; ^{Douglas.Walker@emory.edu} ; Dean P. Jones^b ; ² ; ^{dpjones@emory.edu} ; Claudia M.P. Oller do Nascimento^c ; ³ ; ^{claudia.oller@unifesp.br} ; Christopher J. Barnum^a ; ¹ ; ^{cjbarnum@me.com} ; Malú ; G. Tansey^a ; ^{malu.tansey@emory.edu}
• 关键词：Predatory stress ; Depression ; Metabolic syndrome ; Insulin ; Cholesterol ; Lipocalin-2 ; Metabolomics ; Biliverdin
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：158-172
• 全文大小：1885 K
• 卷排序：59

文摘

Stress and HFHF diet alter adaptive immune responses in hippocampus and liver. Stress and HFHF diet increase insulin and cholesterol plasma levels. Lcn2 may play a key role in the systemic and hippocampal response in obesity. Biliverdin is impacted by HFHF and stress in the context of insulin alterations.