Synthetic isoprenoid analogues for the study of prenylated proteins: Fluorescent imaging and proteomic applications
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- 作者：Yen-Chih Wang ; Mark D. Distefano ; diste001@umn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bioorthogonal labeling ; Farnesylation ; Fluorescent isoprenoids ; Geranylgeranylation ; Prenylomics ; Protein prenylation ; Proteomics
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：64
- 期：Complete
- 页码：59-65
- 全文大小：781 K
文摘
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Protein prenylation is a common post-translational modification in eucaryotes.
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Prenylation involves the addition of farnesyl (C15) and geranylgeranyl (C20) groups.
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Fluorescent isoprenoids have facilitated the study of prenylating enzymes.
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Isoprenoids containing bioorthogonal groups have been used to identify prenylated proteins.