Prenylation differentially inhibits insulin-dependent immediate early gene mRNA expression
详细信息 查看全文
- 作者：J. Lee Franklina ; Maggie O. Amslerb ; Joseph L. Messinaa ; c ; messinaj@uab.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Insulin ; Gene expression ; Transcription ; Immediate early genes ; Prenylation
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：3 June 2016
- 年：2016
- 卷：474
- 期：3
- 页码：594-598
- 全文大小：711 K
文摘
- •
Inhibition of prenylation have non-overlapping and specific effects on insulin-responsive genes.
- •
Inhibition of GGTase-I or FTase had no effect on the insulin-induced initiation/elongation of the β-actin and EGR1 genes.
- •
Initiation/elongation of c-fos and Pip92 mRNAs were more insulin sensitive upon pre-treatment only with the GGTase inhibitor.
- •
HSP60 gene initiation/elongation was more insulin sensitive upon pre-treatment only with the FTase inhibitor.
- •
Inhibition of prenylation may regulate genes via the timing/activity of insulin-induced ERK and/or other MAPK pathways.