Low testosterone and clinical outcomes in Chinese men with type 2 diabetes mellitus - Hong Kong Diabetes Registry

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• 作者：Kitty Kit-Ting Cheung^a ; ^b ; ^{kittyktcheung@cuhk.edu.hk} ; Eric Siu-Him Lau^a ; ^b ; Wing-Yee So^a ; ^b ; Ronald Ching-Wan Ma^a ; ^b ; ^c ; Risa Ozaki^a ; ^b ; Alice Pik-Shan Kong^a ; ^b ; ^c ; Francis Chun-Chung Chow^a ; ^b ; Juliana Chung-Ngor Chan^a ; ^b ; ^c ; Andrea On-Yan Luk^a ; ^b ; ^c
• 关键词：Testosterone ; Type 2 diabetes ; Metabolic syndrome ; Mortality ; Cancer
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：123
• 期：Complete
• 页码：97-105
• 全文大小：499 K
• 卷排序：123

文摘

To assess the implications of low testosterone on cardiovascular risk factors, metabolic syndrome (MES) and clinical outcomes in Chinese men with Type 2 Diabetes (T2D).MethodsA prospective cohort study carried out in a university hospital involving a consecutive cohort of 1239 Chinese men with T2D and a median disease duration of 9 years followed up for 4.8 years. Clinical characteristics, frequency of MES, serum total testosterone and clinical events were analyzed. Multivariate logistic regression was performed to examine the independent association of low testosterone with MES after adjustment for confounding covariates. Cox proportional hazards regression analysis was used to derive hazard ratio for clinical outcomes.ResultsMore men with low testosterone had cardiovascular-renal disease and MES than those with normal testosterone. The adjusted odds ratio (OR) of low testosterone for MES was 2.63 (95% Confidence Interval [CI] 1.56–4.61). After a median follow-up of 4.8 years, the hazard ratio (HR) of low testosterone was 2.22 (95% CI 1.23–4.01) for incident non-prostate cancer. In a multivariate Cox-regression model, the HRs were attenuated but remained significant with adjustment for MES and renal parameters.ConclusionsChinese men with low testosterone had high prevalence of cardiovascular disease and MES with high incidence non-prostate cancer.