Development of prilling process for biodegradable microspheres through experimental designs

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• 作者：Violet Fabien^a ; ^b ; Le Minh-Quan^a ; ^b ; Sergent Michelle^c ; Bastiat Guillaume^a ; ^b ; Tran Van-Thanh^a ; ^b ; ¹ ; Venier-Julienne Marie-Claire^a ; ^b ; ^{venier@univ-angers.fr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：DMSO ; dimethyl sulfoxide ; Eth ; ethanol ; FDA ; food and drug administration ; HCl ; hydrochloric acid ; PEG ; polyethylene glycol ; PLGA ; poly(d ; l-lactic-co-glycolic acids) ; PG ; propylene glycol ; PRX ; piroxicam ; SEM ; scanning electron microscopy ; SD ; standard deviation ; W ; water
• 刊名：International Journal of Pharmaceutics
• 出版年：2016
• 出版时间：10 February 2016
• 年：2016
• 卷：498
• 期：1-2
• 页码：96-109
• 全文大小：2109 K

文摘

The prilling process proposes a microparticle formulation easily transferable to the pharmaceutical production, leading to monodispersed and highly controllable microspheres. PLGA microspheres were used for carrying an encapsulated protein and adhered stem cells on its surface, proposing a tool for regeneration therapy against injured tissue. This work focused on the development of the production of PLGA microspheres by the prilling process without toxic solvent. The required production quality needed a complete optimization of the process. Seventeen parameters were studied through experimental designs and led to an acceptable production. The key parameters and mechanisms of formation were highlighted.