Proliferation of mouse endometrial stromal cells in culture is highly sensitive to lysophosphatidic acid signaling

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• 作者：Shizu Aikawa^a ; ¹ ; Kuniyuki Kano^a ; ^b ; ¹ ; Asuka Inoue^a ; ^c ; Junken Aoki^a ; ^b ; ^{jaoki@m.tohoku.ac.jp}
• 关键词：Lysophosphatidic acid ; Autotaxin ; Endometrial stromal cell ; Primary culture ; G protein-coupled receptor
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：26 February 2017
• 年：2017
• 卷：484
• 期：1
• 页码：202-208
• 全文大小：729 K
• 卷排序：484

文摘

Uterine endometrial stromal cells (ESCs) proliferate rapidly both in vivo and in vitro. ESCs proliferated in vitro in an autocrine fashion. Proliferation of mouse ESCs was prominently suppressed by inhibitors of lysophosphatidic acid (LPA) signaling. LPA receptors, LPA1 and LPA3, had redundant role in supporting the proliferation of ESCs.