N-terminal Dentin Sialoprotein fragment induces type I collagen production and upregulates dentinogenesis marker expression in osteoblasts
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- 作者：Haytham Jahaa ; Dina Huseina ; Yoshio Ohyamaa ; Dongliang Xua ; b ; Shigeki Suzukic ; George T.-J. Huangd ; Yoshiyuki Mochidaa ; mochida@bu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dentinogenesis Imperfecta ; Dentin Sialophosphoprotein (DSPP) ; Dentin Sialoprotein (DSP) ; MC3T3-E1 cells ; Type I collagen
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：6
- 期：Complete
- 页码：190-196
- 全文大小：3025 K
文摘
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Recombinant N-terminal DSP (N-DSP) protein was generated.
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N-DSP mimics the non-sense mutation form of Dentinogenesis Imperfecta type II.
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N-DSP enhances bone formation in clavarial ex vivo cultures.
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N-DSP accelerates osteoblast proliferation.
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N-DSP upregulates type I collagen and Dspp expression in non-odontogenic osteoblasts.