Gene expression profiling of bone marrow-derived stromal cells seeded onto a sandblasted, large-grit, acid-etched-treated titanium implant surface: The role of the Wnt pathway
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- 作者：Guoli Yang ; Wen Fang ; Tie Liu ; Fuming He ; Xuepeng Chen ; Yi Zhou ; Xiaoxu Guan ; gsunrise@aliyun.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：SLA treatment ; Osseointegration ; Microarray ; LRP5 ; β-Catenin ; Wnt pathway
- 刊名：Archives of Oral Biology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：61
- 期：Complete
- 页码：71-78
- 全文大小：1646 K
文摘
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19 genes were significantly altered after SLA treatment, including LRP5 and Lect2.
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Wnt pathway was the most important signals after SLA treatment.
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LRP5 positively regulated SLA-induced enhanced osteogenic differentiation of
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BMMSCs.
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β-Catenin/LRP5 pathway was responsible for this enhanced osteogenic response.