A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development
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- 作者：Justyna Nitarska1 ; Jacob G. Smith1 ; William T. Sherlock1 ; Michele M.G. Hillege1 ; Alexi Nott1 ; 4 ; William D. Barshop2 ; Ajay A. Vashisht2 ; James A. Wohlschlegel2 ; Richard Mitter3 ; Antonella Riccio1 ; 5 ; a.riccio@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：epigenetics ; chromatin remodeling ; CHD proteins ; NuRD complex ; mouse brain ; cortical development ; neural radial migration ; neural progenitors ; cortical laminar fate specification
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：17
- 期：6
- 页码：1683-1698
- 全文大小：8948 K
文摘
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The ATPases CHD3, CHD4, and CHD5 are mutually exclusive subunits of the NuRD complex
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CHD3, CHD4, and CHD5 regulate distinct and non-redundant aspects of cortical development
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Loss of each CHD leads to specific defects of neuronal proliferation and migration
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CHD3, CHD4, and CHD5 regulate distinct set of genes essential for brain development