Strong evolutionary conservation allows lessons learnt from simple organisms to be applied to ageing studies in humans.

Core conserved biochemical pathways of ageing include insulin-like signalling and integration of nutrient and stress sensing through the mTOR kinase.

Removal of senescent cells in mice improves health in later life.

The genetic causes of premature ageing syndrome in humans suggest treatment regimes that may be applicable to the ageing population.

Conserved biochemical pathway of ageing in model organisms highlight drug targets for improvement of ageing outcomes.