Direct cyclization of 1,3-diaryl propargylic alcohols with β-dicarbonyl compounds by palladium-boric acid dual-catalyst system

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• 作者：Masahiro Yoshida^a ; ^{yoshida@ph.bunri-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Shoko Ohno^b ; Sayaka Eguchi^a ; Tomotaka Mizuguchi^b ; Kenji Matsumoto^a ; Kosuke Namba^b
• 关键词：Cyclization ; β-Dicarbonyl compounds ; Lewis acids ; Palladium ; Propargyl alcohols
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：8 September 2016
• 年：2016
• 卷：72
• 期：36
• 页码：5633-5639
• 全文大小：1123 K

文摘

Palladium and boric acid-catalyzed cyclization of underivatized 1,3-diaryl propargylic alcohols with 1,3-cyclohexanediones has been developed. Boric acid plays a role for the efficient activation of the propargylic alcohols. Various substituted tetrahydrobenzofuranones were obtained in moderate to good yields. Reactions using 4-hydroxy-2-pyrones as the nucleophile also proceeded to afford the substituted dihydrofuropyranones.