Design and synthesis of a series of serine derivatives as small molecule inhibitors of the SARS coronavirus 3CL protease

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• 作者：Hiroyuki Konno^a ; ^{konno@yz.yamagata-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Masaki Wakabayashi^a ; Daiki Takanuma^a ; Yota Saito^a ; Kenichi Akaji^b ; ^{akaji@mb.kyoto-phu.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：SARS CoV ; SARS 3CL protease ; Serine derivative ; Docking simulation ; Cathepsin B ; Cytotoxicity
• 刊名：Bioorganic & Medicinal Chemistry
• 出版年：2016
• 出版时间：15 March 2016
• 年：2016
• 卷：24
• 期：6
• 页码：1241-1254
• 全文大小：3213 K

文摘

Synthesis of serine derivatives having the essential functional groups for the inhibitor of SARS 3CL protease and evaluation of their inhibitory activities using SARS 3CL R188I mutant protease are described. The lead compounds, functionalized serine derivatives, were designed based on the tetrapeptide aldehyde and Bai’s cinnamoly inhibitor, and additionally performed with simulation on GOLD softwear. Structure activity relationship studies of the candidate compounds were given reasonable inhibitors ent-3 and ent-7k against SARS 3CL R188I mutant protease. These inhibitors showed protease selectivity and no cytotoxicity.