Porcine deltacoronavirus nsp5 inhibits interferon-β production through the cleavage of NEMO

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• 作者：Xinyu Zhu^a ; ^c ; Liurong Fang^a ; ^c ; Dang Wang^a ; ^c ; ^{wangdang511@126.com} ; ^{wangdang@mail.hzau.edu.cn} ; Yuting Yang^a ; ^c ; Jiyao Chen^a ; ^c ; Xu Ye^a ; ^c ; Mohamed Frahat Foda^a ; ^b ; Shaobo Xiao^a ; ^c ; ^{vet@mail.hzau.edu.cn}
• 关键词：Porcine deltacoronavirus ; nsp5 ; 3C-like protease ; Interferon-β ; NEMO
• 刊名：Virology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：502
• 期：Complete
• 页码：33-38
• 全文大小：1204 K
• 卷排序：502

文摘

PDCoV nsp5 inhibits type I IFN production by means of its protease activity. PDCoV nsp5 cleaves NEMO to disrupt RIG-I/MDA5 signaling. PDCoV nsp5 recognizes Q231 of NEMO as the P1 position for cleavage. The cleaved NEMO products fail to induce the transcription of ISGs.