Orobol derivatives and extracts from Cudrania tricuspidata fruits protect against 6-hydroxydomamine-induced neuronal cell death by enhancing proteasome activity and the ubiquitin/proteasome-dependent degradation of α-synuclein and synphilin-1

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• 作者：Dong-Woo Kim^a ; Jaeyoung Kwon^b ; Su Jin Sim^c ; Dongho Lee^d ; ^{dongholee@korea.ac.kr} ; Woongchon Mar^a ; ^{mars@snu.ac.kr}
• 关键词：6-OHDA ; 6-hydroxydomamine ; PD ; Parkinson&rsquo ; s disease ; PARP ; poly (ADP-ribose) polymerase ; ROS ; reactive oxygen species ; UPP ; ubiquitin-proteasome pathway ; UPS ; ubiquitin-proteasome system ; CTE50 ; 50% ethanol extract from Cudrania tricuspidata fruits ; OB ; orobol ; POB ; 6-prenylorobol ; DPOB ; 6 ; 8-diprenylorobol
• 刊名：Journal of Functional Foods
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：29
• 期：Complete
• 页码：104-114
• 全文大小：2054 K
• 卷排序：29

文摘

The orobol derivatives and CTE 50 inhibit neuronal cell death and ROS generation. The orobol derivatives and CTE 50 protect 6-OHDA-induced proteasome dysfunction. The orobol derivatives and CTE 50 inhibit ubiquitination of α-synuclein, synphilin-1.