Comparison of miRNA signature versus conventional biomarkers before and after off-pump coronary artery bypass graft

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• 作者：Fatemeh Pourrajab^a ; ^b ; Fereshteh Torkian Velashani^a ; Masoud Khanaghaei^a ; Seyedhossein Hekmatimoghaddam^c ; ^d ; ^{shhekmati2002@yahoo.com} ; ^{hekmati@ssu.ac.ir} ; Mahdi Rahaie^e ; Mohamad Reza Zare-Khormizi^f
• 关键词：miRNAs ; microRNAs ; cTnI ; cardiac troponin I ; CK ; creatine kinase ; UA ; uric acid ; OCABG ; off-pump coronary artery bypass graft ; CAD ; coronary artery disease ; CRP ; C-reactive protein ; ECs ; endothelial cells ; SDF-1 ; stromal cell-derived factor 1 ; EF% ; ventriclular ejection fraction
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：134
• 期：Complete
• 页码：11-17
• 全文大小：1309 K
• 卷排序：134

文摘

Plasma microRNAs have advantages over conventional biomarkers for cardiac injuries. There is a strong correlation between plasma miR-499 and cTnI in CABG patients. A strong correlation exists between plasma miR-126 and uric acid in CABG patients. Release of miR-499 and miR-126 depends on myocardial and endothelial damage, respectively. The miRNA signature may reflect response to cardiac medications or interventions.