G protein coupled receptor interactions with cholesterol deep in the membrane

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• 作者：Samuel Genheden^a ; ¹ ; Jonathan W. Essex^a ; ^b ; Anthony G. Lee^b ; ^c ; ^{agl@soton.ac.uk}
• 关键词：CGMD ; coarse-grained molecular dynamics ; EC ; extracellular ; GPCR ; G-protein coupled receptor ; IC ; intracellular ; POPC ; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine ; TM ; trans-membrane
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1859
• 期：2
• 页码：268-281
• 全文大小：2654 K
• 卷排序：1859

文摘

Simulations detect interactions between cholesterol and GPCRs deep in the membrane. These interactions change on agonist binding. Requirements for interaction are just a hydrogen bond partner and a hole or cleft. These interactions represent a new way in which cholesterol could affect membrane protein function.