G protein-coupled estrogen receptor enhances melanogenesis via cAMP-protein kinase (PKA) by upregulating microphthalmia-related transcription factor-tyrosinase in melanoma

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• 作者：Min Sun^a ; ¹ ; Hong-fu Xie^a ; ¹ ; Yan Tang^a ; Shang-qing Lin^a ; Jin-mao Li^a ; Shu-na Sun^c ; Xing-lin Hu^b ; Ying-xue Huang^a ; Wei Shi^a ; Dan Jian^a ; ^{569085332@qq.com}
• 关键词：GPR30 ; G protein-coupled estrogen receptor ; PKA ; protein kinase ; MITF ; microphthalmia-related transcription factor ; TYR ; tyrosinase
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：165
• 期：part_PB
• 页码：236-246
• 全文大小：2997 K
• 卷排序：165

文摘

Agonist and antagonist treatment altered GPER activation in A375 and B16 cells. GPER upregulation upregulated TYR and MITF expression and TYR activity. GPER upregulation promoted cell proliferation and melanogenesis in A375 cells. GPER enhances melanin synthesis via cAMP-PKA-MITF-TYR signaling. GPER is a potential drug target for chloasma treatment.