HSP90AB1: Helping the good and the bad
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- 作者：Michael Haase ; michael.haase@uniklinikum-dresden.de" class="auth_mail" title="E-mail the corresponding author ; Guido Fitze
- 关键词：17-DMAG ; 17-dimethylaminoethylamino-17-demethoxy-geldanamycin ; AD ; Alzheimer's disease ; Ago ; argonaute protein ; AHA ; activator of heat shock 90 kDa protein ATPase homolog ; AHR ; arylhydrocarbon receptor ; AIF ; apoptosis-inducing factor ; AOA ; anti-ovarian antibodies ; AR ; androgen receptor ; Arp2/3 ; actin related/released protein 2/3 ; ASCI ; acute spinal cord injury ; B[a]P ; Benzo[a]pyrene ; BAZF ; BCL-6 associated zinc finger protein ; Bcl ; B-cell lymphoma protein (influences apoptosis) ; BPD ; bronchopulm
- 刊名：Gene
- 出版年：2016
- 出版时间：10 January 2016
- 年：2016
- 卷：575
- 期：2
- 页码：171-186
- 全文大小：938 K
文摘
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This is a review on HSP90AB1 (heat shock protein 90 kDA alpha, class B, member 1), also known as HSP90beta.
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HSP90AB1 binds to all kinds of proteins including steroid hormone receptors, transcription factors, ubiqitin ligases and kinases.
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HSP90AB1 is a chaperone that stabilizes proteins in a properly folded structure, but is also involved in protein transport and degradation.
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Inhibition of HSP90AB1 function is a promising therapeutic approach for a variety of diseases including cancer and inflammatory diseases.