Neuroactive steroids and the peripheral nervous system: An update

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• 作者：Silvia Giatti^a ; Simone Romano^a ; Marzia Pesaresi^a ; Gaia Cermenati^a ; Nico Mitro^a ; Donatella Caruso^a ; Marc J. Tetel^b ; Luis Miguel Garcia-Segura^c ; Roberto C. Melcangi^a ; ^{roberto.melcangi@unimi.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：3伪-diol ; 5伪-androstane-3伪 ; 17尾-diol ; 5伪-R ; 5伪-reductase ; 17尾-E ; 17尾-estradiol ; AR ; androgen receptor ; DHEA ; dehydroepiandrosterone ; DHP ; dihydroprogesterone ; DHT ; dihydrotestosterone ; DRG ; dorsal root ganglia ; P0 ; glycoprotein zero ; LXR ; liver X receptor ; NCV ; nerve conduction velocity ; P450scc ; P450 side chain cleavage ; PMP22 ; peripheral myelin protein 22 ; PNS ; peripheral nervous system ; PREG ; pregnenolone ; PROG ; progesterone ; PR ; progesterone receptor ; PGRMC1 ; progesterone receptor membrane co
• 刊名：Steroids
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：103
• 期：Complete
• 页码：23-30
• 全文大小：1045 K

文摘

In the present review we summarize observations to date supporting the concept that neuroactive steroids are synthesized in the peripheral nervous system, regulate the physiology of peripheral nerves and exert notable neuroprotective actions. Indeed, neuroactive steroids have been recently proposed as therapies for different types of peripheral neuropathy, like for instance those occurring during aging, chemotherapy, physical injury and diabetes. Moreover, pharmacological tools able to increase the synthesis of neuroactive steroids might represent new interesting therapeutic strategy to be applied in case of peripheral neuropathy.