The Cilium: Cellular Antenna and Central Processing Unit

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• 作者：Jarema J. Malicki¹ ; ^{j.malicki@sheffield.ac.uk} ; Colin A. Johnson² ; ^{c.johnson@leeds.ac.uk}
• 关键词：primary cilium ; ciliogenesis ; cell cycle ; actin cytoskeleton ; mTOR pathway ; autophagy
• 刊名：Trends in Cell Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：27
• 期：2
• 页码：126-140
• 全文大小：4360 K
• 卷排序：27

文摘

Cilia mediate an astonishing diversity of processes. Recent advances provide unexpected insights into the regulatory mechanisms of cilium formation, and reveal diverse regulatory inputs that are related to the cell cycle, cytoskeleton, proteostasis, and cilia-mediated signaling itself. Ciliogenesis and cilia maintenance are regulated by reciprocal antagonistic or synergistic influences, often acting in parallel to each other. By receiving parallel inputs, cilia appear to integrate multiple signals into specific outputs and may have functions similar to logic gates of digital systems. Some combinations of input signals appear to impose higher hierarchical control related to the cell cycle. An integrated view of these regulatory inputs will be necessary to understand ciliogenesis and its wider relevance to human biology.