From the Medical Board of the National Psoriasis Foundation: Treatment targets for plaque psoriasis

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• 作者：April W. Armstrong ; MD ; MPH^a ; ^{aprilarmstrong@post.harvard.edu} ; Michael P. Siegel ; PhD^b ; Jerry Bagel ; MD^c ; ^d ; Erin E. Boh ; MD ; PhD^e ; Megan Buell^b ; Kevin D. Cooper ; MD^f ; Kristina Callis Duffin ; MD ; MS^g ; Lawrence F. Eichenfield ; MD^h ; Amit Garg ; MDⁱ ; Joel M. Gelfand ; MD ; MSCE^j ; Alice B. Gottlieb ; MD ; PhD^k ; John Y.M. Koo ; MD^l ; Neil J. Korman ; MD ; PhD^f ; Gerald G. Krueger ; MD^g ; Mark G. Lebwohl ; MD^m ; Craig L. Leonardi ; MDⁿ ; Arthur M. Mandelin ; MD ; PhD^o ; M. Alan Menter ; MD^p ; Joseph F. Merola ; MD ; MMSC^q ; David M. Pariser ; MD^r ; ^s ; Ronald B. Prussick ; MD ; FRCP^t ; Caitriona Ryan ; MD^p ; Kara N. Shah ; MD^u ; Jeffrey M. Weinberg ; MD^m ; MaryJane O.U. Williams ; MD^a ; Jashin J. Wu ; MD^v ; Paul S. Yamauchi ; MD ; PhD^w ; Abby S. Van Voorhees ; MD^r
• 关键词：biologics ; body surface area ; outcome measures ; Physician Global Assessment ; psoriasis ; systemic therapies ; treat to target ; treatment ; treatment goals
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：76
• 期：2
• 页码：290-298
• 全文大小：263 K
• 卷排序：76

文摘

An urgent need exists in the United States to establish treatment goals in psoriasis.ObjectiveWe aim to establish defined treatment targets toward which clinicians and patients with psoriasis can strive to inform treatment decisions, reduce disease burden, and improve outcomes in practice.MethodsThe National Psoriasis Foundation conducted a consensus-building study among psoriasis experts using the Delphi method. The process consisted of: (1) literature review, (2) pre-Delphi question selection and input from general dermatologists and patients, and (3) 4 Delphi rounds.ResultsA total of 25 psoriasis experts participated in the Delphi process. The most preferred instrument was body surface area (BSA). The most preferred time for evaluating patient response after starting new therapies was at 3 months. The acceptable response at 3 months postinitiation was either BSA 3% or less or BSA improvement 75% or more from baseline. The target response at 3 months postinitiation was BSA 1% or less. During the maintenance period, evaluation every 6 months was most preferred. The target response at every 6 months maintenance evaluation is BSA 1% or less.LimitationsAlthough BSA is feasible in practice, it does not encompass health-related quality of life, costs, and risks of side effects.ConclusionWith defined treatment targets, clinicians and patients can regularly evaluate treatment responses and perform benefit-risk assessments of therapeutic options individualized to the patient.