Selfish brain and selfish immune system interplay: A theoretical framework for metabolic comorbidities of mood disorders

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• 作者：Ana Sayuri Yamagata^a ; ^b ; ^{ana.yamagata@usp.br} ; ^{yamagatasayuri@gmail.com} ; Rodrigo Barbachan Mansur^b ; ^c ; Lucas Bortolotto Rizzo^b ; Tatiana Rosenstock^d ; Roger S. McIntyre^c ; Elisa Brietzke^b
• 关键词：Bipolar disorder ; Major depressive disorder ; Brain energy metabolism ; Immune system energy metabolism ; Metabolic syndrome ; Inflammation
• 刊名：Neuroscience & Biobehavioral Reviews
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：72
• 期：Complete
• 页码：43-49
• 全文大小：1278 K
• 卷排序：72

文摘

The brain and the immune system are energy consumptive and are the highest hierarchical priority in energy distribution. Psychological stress and immune dysfunction in mood disorders may contribute to malfunctioning of the mechanisms of the “selfish” brain and immune system. Such malfunctioning may result in comorbidities in mood disorders.