Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation
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- 作者：F. Bonacinaa ; 1 ; S.S. Barbierib ; 1 ; L. Cutulia ; P. Amadiob ; A. Donic ; M. Sironic ; S. Tartaric ; A. Mantovanic ; B. Bottazzic ; C. Garlandac ; E. Tremolia ; b ; A.L. Catapanoa ; d ; alberico.catapano@unimi.it" class="auth_mail" title="E-mail the corresponding author ; G.D. Norataa ; e ; f ; danilo.norata@unimi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：PTX3 ; Arterial thrombosis ; P-selectin ; Vessel wall ; Collagen and fibrinogen
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1862
- 期：6
- 页码：1182-1190
- 全文大小：1930 K
文摘
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PTX3 deficiency in non-hematopoietic cells results in increased arterial thrombosis.
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Defects in the PTX3-P-selectin axis are not responsible for increased arterial thrombosis.
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PTX3 might limit the pro-thrombotic potential of fibrinogen and collagen on platelets adhesion and aggregation.